What insights can behavioral science give us about leaders in business, politics or innovation and the reactions and interplay with those they lead? Recent headlines from all sectors of society, whether in business, government, or academia bring the role of leadership to light. We also continue to find differences between males and females in terms of percentage representation in leadership positions. What leadership styles, personalities and behaviors (e.g. “High Mach”) are successful and on which metrics? What can we learn about reward mechanisms and organizational design vis-à-vis these findings? While the recent headlines are certainly not new, our goal is to objectively explore the latest findings in game theory, anthropology, biology, economics, psychology and other behavioral sciences to shed new light on this topic.